dimethyl sulfoxide?
Apr 24, 2007 by a d | Posted in Chemistry
what is this?
Dimethyl sulfoxide (DMSO) is an organic solvent. It has many properties. It was once used in drug systems where the drug would be dissolved in DMSO and then applied on a patch to the skin. This was due to that DMSO could be absorbed through the skin with any dissolved compounds in it. Patients often noticed that they would taste something in there mouth then using his method. It is not used as much nowadays as DMSO is found to be dangerous to health in some cases.
One of the main uses is its use as a reaction solvent in organic systems, due to is high boiling point and its ability to dissolve organic compounds. It is specially used then you need higher temperatures to kick start a reaction.
Another use is in NMR studies were deuterated DMSO or d-6 DMSO is used. With the hydrogen being replaced with deaturium they do not show up on a proton NMR spectra. It is the second mostly commonly use solvent for this purpose then compounds don't dissolved in deuterated chloroform.
Mr Hex Vision | Apr 24, 2007
It is a nontoxic liquid absorbed through the skin. Some persons think that it is a miracle drug of sorts that has never been approved by the Food & Drug Administration because of a conspiracy. Google it, and you will find that a miraculous new drug has been overlooked, or not.
steve_geo1 | Apr 24, 2007
will dimethyl sulfoxide (dmso) permit bee venom to penetrate the skin and get into the bloodstream?
Oct 09, 2009 by D F V 11789 | Posted in Medicine
DMSO is a polar aprotic with solvating power to penetrate the skin and get into the bloodstream. Would it be compatible for use with honey bee venom in therapeutic applications?
Interesting question.
We used it on horses. (my best friend is an equine vet, and I was often her go-fer) I don't even know if it is still available in most states.
Interestingly, my dog is now almost 14 (rottie/dobie cross) and very arthritic. Poor little man could hardly move. A year and a half ago he was hit on the nose with a rattle snake, and fully envenomated... he was, in a word, on his way out.
We rushed him to the vet, and the only reason he even survived was because he weighs almost 100 lbs. and got antivenom.
The antivenom saved him, and 3 days later and $2000 shorter, he got to come home. His head looked like that of a Shar pai.
However, 7 days later, his arthritis was 80% better !!!!!!!!! he regained muscle mass in his hind limbs, and was dancing around like a puppy, for almost 8 months !!!!!!!!! My vet found nothing in the literature, but there are a few things about arthritis and venoms in the literature on the web.
And people have allowed bees to sting them over the joints that are affected and gotten some great relief, and no one really knows the mechanism, as far as I am aware.
As well, interestingly, my dad kept bees since he was a child, and was often stung. He never had arthritis... not even the slightest, and he lived to be 87 or so.
ladyren | Oct 09, 2009
Dimethyl Sulfoxide, question for doctors/nurses?
Sep 29, 2007 by Jessica | Posted in Other - Diseases
I am taking treatments for Interstitial cystitis and they are doing the catheter treatments using Dimethyl Sulfoxide. Can this cause extreme bloating? Since I have been taking this, I have been very bloated.
Adverse reactions reported in those using DMSO for treatment of interstitial cystitis include garlic-like taste, transient chemical cystitis, bladder spasm, discomfort, allergic reactions and anaphylactoid reactions. Adverse reactions for topical use include garlic-like taste, local dermatitis, nausea, vomiting, headache, burning eyes and sedation. Concomitant use of DMSO and sulindac may cause peripheral neuropathy.
if you're interested in knowing more, check this site
http://www.pdrhealth.com/drug_info/nmdru gprofiles/nutsupdrugs/dim_0098.shtml
InuYasha | Sep 29, 2007
Another letter on azide, plus dimethyl sulfoxide oxidation | The ...
by Jyllian Kemsley
, 4130 ], A researcher at Los Alamos National Laboratory scaled up this reaction from 1.5 mL to 12 mL DMSO and conducted the reaction in a Teflon-lined Parr vessel ( model number 4745 ADB ) that was placed on the bottom of a convection oven set to 150 °C and left for the weekend. The following Monday, the researcher saw that the bottom flange lip of the Parr vessel had sheared off as intended when overpressured. This shearing event was energetic enough to dent the bottom of the oven, causing the metal plate of the oven bottom to contact the heating elements, which resulted in an electrical shortage.
We were initially concerned that perchlorate salts formed during the chemical synthesis and may have detonated with the DMSO, but we have found no evidence supporting this hypothesis. Additional experiments were conducted with appropriate engineered controls to protect against a recurrence. Although nearly identical reaction conditions were used, the Parr vessel did not rupture. However, a thermocouple placed on the Parr vessel recorded an 11.4 °C temperature increase lasting approximately one hour after approximately 27 hours of heating.
Although the exact nature of this energetic release is uncertain, we have concluded that several events may have contributed. First and foremost, the exothermic nature of the oxidation of DMSO was not communicated in the publication, and the experiment was conducted close to the boiling point of DMSO (189 °C). Second, an old Parr vessel (manufactured between 1969 and 1973) with an uncertain history of use was used for experimental chemistry; the vessel was not equipped with a burst disk, which is now the preferred design. Finally, the Parr vessel was placed on the bottom plate of the oven, which was later found to have a temperature that may have been on the order of
35 °C higher than the oven set temperature of 150 °C. We believe these were critical factors that resulted in the energetic release during the experiment. …
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His facile new chemical route to CZTSSe thin film solar cells is based on spin-coating a solution of highly soluble, inexpensive, and commercially available precursors in an environmentally friendly non-toxic solvent (ie dimethyl sulfoxide) to form